PRESIDENT Donald Trump has vowed not to participate in next week's debate with Democratic nominee Joe Biden after organisers announced it will take place virtually because of the president's diagnosis of Covid-19.

"I'm not going to do a virtual debate" with Biden, Trump told Fox News, moments after the Commission on Presidential Debates announced the changes.

That cast serious doubts on whether the event will go forward, even as Biden's campaign vowed that its candidate will participate.

"Vice President Biden looks forward to speaking directly to the American people," deputy Biden campaign manager Kate Bedingfield said in a statement.

The announcement from the non-partisan Commission on Presidential Debates cited a need "to protect the health and safety of all involved with the second presidential debate".

The candidates will "participate from separate remote locations" while the participants and moderator remain in Miami, it said.

The announcement came a week before Biden and Trump were scheduled to face off in Miami.

Trump was diagnosed with coronavirus a week ago and but in a Tuesday tweet said he looked forward to debating Biden on stage in Miami, "It will be great!" he tweeted.

Biden, for his part, said he and Trump "shouldn't have a debate" as long as the president remains Covid-19 positive.

Biden told reporters in Pennsylvania that he was "looking forward to being able to debate him" but said "we're going to have to follow very strict guidelines".

Trump was still contagious with the virus when he was discharged from Walter Reed National Military Medical Centre on Monday but his doctors have not provided any detailed update on his status.

According to the Centres for Disease Control and Prevention, those with mild to moderate symptoms of Covid-19 can be contagious for as many as - and should isolate for at least - 10 days.